J. Koji Lum
Education:
PhD, University of Hawaii, Manoa 1995
About:
Associate Professor of Anthropology. Molecular anthropology, forensic genetics, malaria, epidemiology; Pacific Islands.
Contact:
klum@binghamton.edu
Research Interests:
My initial research interests involved comparing patterns of genetic, linguistic, and geographic relatedness among Pacific island populations to gain insight into their origins and post-settlement gene flow. More recently my research has expanded to include malaria research throughout the tropics. These studies involve examining human genes that confer resistance and susceptibility to malaria, the genetics of malaria transmitting anopheles mosquitoes (species identification, population structure, and insecticide resistance), and the influence of human migration on disease. The latter includes the analyses of commensal organisms (rats and geckos) and domestic plants (kava) as proxies of human movement and exchange. Another focus of my research is the analyses of ancient DNA from archaeological contexts throughout the Pacific and forensic DNA samples from WWII remains and contemporary forensic settings. I am also involved in projects examining the influence somatic mitochondrial mutations in neuronal tissues and the development of neurodegenerative disease and of neurotransmitter receptor polymorphisms on sexual behavior.
Selected Bibliography:
Chan CW, Garruto RM, and Lum JK. 2006. Paleoparasite Populations from Archived Sera: Insights into Chloroquine Drug Resistance in Papua New Guinea. Journal of Infectious Disease 194:1023-1024.
Chan CW, Lynch D, Spathis R, Hombhanje FW, Kaneko A, Garruto RM, and Lum JK. 2006. Flashback to the 60s: Utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific. Acta Tropica 99: 15-22.
Tsukahara T, FW Hombhanje, JK Lum, I Hwaihwanje, A Masta, A Kaneko, and T Kobayakawa (2006) Austronesian origin of the 27 base pair deletion of the erythrocyte band 3 gene in East Sepik, Papua New Guinea inferred from mtDNA analysis. Journal of Human Genetics.
Ubalee, R, T Tsukahara, M Kikuchi, JK Lum, M Dzodzomenyo, A Kaneko, and K Hirayama (2005) TNF-a promoter polymorphism and malaria in Vanuatu. Tropical Medicine and International Health 10:544-549.
Hombhanje FW, I Hwaihwanje, T Tsukahara, J Saruwatari, M Nakagawa, H Osawa, MM Paniu, N Takahashi, JK Lum, B Aumora, A Masta, M Sapuri, T Kobayakawa, A Kaneko, and T Ishizaki (2005) The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria. British Journal of Clinical Pharmacology 59:298-301.
Akhwale, WS, JK Lum, A Kaneko, H Eto, C Obonyo, A Björkman, and T Kobayakawa (2004) Anemia and unstable malaria at different altitudes in the western highlands of Kenya. Acta Tropica 91:167-175.
Mita, T, A Kaneko, JK Lum, IL Zungu, T Tsukahara, H Eto, T Kobayakawa, A Björkman, and K Tanabe (2004) Expansion of wild type allele rather than back mutation in Pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi. Molecular Biochemistry and Parasitology 135:159-163.
Cann, RL and JK Lum (2004) Dispersal Ghosts in Oceania. Am J Hum Biol, 16:1-12.
Wirth, T, X Wang, RP Novick, JK Lum, M Blaser, D Falush, and M Achtman (2004) Deciphering recent human history via sequences from Helicobacter pylori: lessons from the Ladakh. Proceedings of the National Academy of Sciences USA, 101:4746-4751.
Lum, JK, A Kaneko, K Tanabe, N Takahashi, A Björkman, and T Kobayakawa (2004) Malaria dispersal among islands: human and Plasmodium falciparum gene flow in Vanuatu. Acta Tropica, 90:181-185.
Masta, A, JK Lum, T Tsukahara, I Hwaihwanje, A Kaneko, MM Paniu, M Sapuri, N Takahashi, T Ishizaki, T Kobayakawa, and FW Hombhanje (2003) Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia. Pharmacogenetics, 13:697-700.
Yusuf, I, MW Djojosubroto, R Ikawati, K Lum, A Kaneko, and S Marzuki (2003) Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia. in: Tropical Diseases: From Molecule to Bedside. S Marzuki ed. Kluwer Academic Pub.
Yusuf, I, MW Djojosubroto, R Ikawati, K Lum, A Kaneko, and S Marzuki (2003) Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia. Adv Exp Med Biol, 531:37-46.
Mita, T, A Kaneko, JK Lum, B Bwijo, M Takechi, IL Zungu, T Tsukahara, T Kobayakawa, K Tanabe, and A Bjorkman (2003) Recovery of chloroquine sensitivity and low prevalence of pfcrt K76T following the withdrawal of chloroquine in Malawi. American Journal of Tropical Medicine and Hygiene 68:413-415.
Bwijo, B, A Kaneko, M Takechi, IL Zungu, Y Moriyama, JK Lum, T Tsukahara, T Mita, N Takahashi, Y Bergqvist, A Björkman, and T Kobayakawa (2003a) High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Tropica, 85:363-373.
Bwijo, B, A Kaneko, JK Lum, IL Zungu, T Tsukahara, T Mita, and T Kobayakawa (2003b) Antimalarial Drug Efficacy in Plasmodium falciparum Infections in Malawi, Seven Years After Switching From Chloroquine to Sulfadoxine/pyrimethamine. Journal of Tokyo Women's Medical University, 73:1-13.
Lum, JK, LB Jorde, and W Schiefenhovel (2002) Affinities among Melanesians, Micronesians, and Polynesians: a neutral, biparental genetic perspective. Human Biology 74(3): 413-430.
Ciminelli BM, F Pompei1, M Relucenti, JK Lum, J Simpore, G Spedini, C Martínez- Labarga, and M Pardo (2002) Confirmation of the potential usefulness of two human beta globin pseudogene markers to estimate gene flows to and from sub- saharan Africans. Human Biology, 74(2): 243-252.
Bwijo, B, A Kaneko, T Tsukahara, M Takechi, JK Lum, and T Kobayakawa (2001) Findings of decreased chloroquine resistance in Plasmodium falciparum isolates of Malawi. Clinical Parasitology, 12: 145-147.
Lum, JK (2001) The colonization of Remote Oceania and the drowning of Sundaland. in: Genetic, Linguistic and Archaeological Perspectives on Human Diversity in Southeast Asia. M Seielstad, L Jin, and C Xiao eds. World Scientific Publishing Co.
Handoko, HY, JK Lum, Gustiani, Rismalia, H Kartapradja, ASM Sofro, and S Marzuki (2001) Length variations in the COII-tRNALys intergenic region of mitochondrial DNA in Indonesian populations. Human Biology, 73(2): 205-223.
Lum, JK (2001) Comment to Terrell, JE, KM Kelly, and P Rainbird. Forgone conclusions? An analysis of the concepts of "Austronesians" and "Papuans". Current Anthropology, 42: 97-124